Cast
| Real Name | Character | Appeared In |
|---|---|---|
| Jennifer Love Hewitt | Melinda Gordon | 44 episodes, 2005-2007 |
| David Conrad | Jim Clancy | 44 episodes, 2005-2007 |
| Aisha Tyler | Andrea Moreno | 22 episodes, 2005-2006 |
| Camryn Manheim | Delia Banks | 21 episodes, 2006-2007 |
| Jay Mohr | Professor Rick Payne | 14 episodes, 2006-2007 |
| Tyler Patrick Jones | Ned Banks | 9 episodes, 2006-2007 |
| Dariush Kashani | Bobby Tooch | 5 episodes, 2005-2006 |
| June Squibb | Grandma | 4 episodes, 2005-2006 |
| David Ramsey | Will | 3 episodes, 2005-2006 |
| Dondre Whitfield | Mitch Marino | 3 episodes, 2005-2006 |
| Grace Fulton | Young Melinda | 3 episodes, 2005-2006 |
| Jordan Dang | Dylan | 3 episodes, 2005-2006 |
| Scott Rinker | Reggie | 3 episodes, 2006 |
| Jon Seda | John Gregory | 2 episodes, 2006 |
| Chris Ellis | Ghost Pilot | 2 episodes, 2006 |
| Tim Guinee | Charlie Filbert | 2 episodes, 2006 |
| Michael Landes | Kyle McCall | 2 episodes, 2006 |
| John Walcutt | Wide Brim | 2 episodes, 2006 |
| Christine Baranski | Faith Clancy | 2 episodes, 2005 |
| Marco Sanchez | Freddy Diaz | 2 episodes, 2006 |
| Thomas F. Wilson | Tim Flaherty | 2 episodes, 2006-2007 |
| John Eric Bentley | Army Chaplain | 2 episodes, 2005-2006 |
| Sarah Hunley | Old Nurse | 2 episodes, 2005-2006 |
| Jeffrey Hutchinson | Father at Funeral | 2 episodes, 2005-2006 |
| Graham Miller | Guardian Spirit | 2 episodes, 2005-2006 |
| Wendy Phillips | Diane Shields | 2 episodes, 2005-2006 |
| Whitney Anderson | Paige | 2 episodes, 2005 |
| Christian Camargo | Brad Paulson | 2 episodes, 2005 |
| Robert LaSardo | Crash Victim | 2 episodes, 2005 |
| Karen Maruyama | Heather | 2 episodes, 2005 |
| Nate Torrence | Waiter | 2 episodes, 2005 |
| Anne Archer | Beth Gordon | 2 episodes, 2006 |
| Rachel Cannon | Amy Fields | 2 episodes, 2006 |
| Juan Jose Dubon | Ghost | 2 episodes, 2006 |
| Richie Rayfield | Club Bartender | 2 episodes, 2006 |
| Adam Thompson | Young Jim | 2 episodes, 2006 |
| Tamara Braun | Brenda Sanborn | 2 episodes, 2007 |
| Jonas Neal | Villager | 2 episodes, 2007 |
| Jayma Mays | Jennifer Billing | 1 episode, 2007 |
